Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → Pyrimidine-2-carbonyl chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | Pyrimidine-2-carboxylic acid hydrochloride | HCID 54594277 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | Pyrimidine-2-carbonyl chloride | HCID 18403666 | 67% |
반응 단계
A stirred mixture of 0.837 g of 2-pyrimidinecarboxylic acid hydrochloride (prepared as described in S. Gronowitz et al. Ark. Chem, 1964, 22, 66-82), 30 mL of CHCl3 and 2 mL of thionyl chloride was heated at reflux for 12 h. After cooling to r.t., the suspension was filtered and the filtrate was evaporated to dryness in vacuo to afford 0.306 g (67%) of the title compound as a green solid used in the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06399614B1 |
| 출처 데이터셋 | uspto-grants-2002_06 |
| ORD ID | ord-bb4e96babe1c46cda69290e79d07af90 |
| 출처 메모 | uspto-grants-2002_06 |