Thionyl Chloride → HCID 15895595, compound

HRID 2184992Notes

Reaction equation

HRID 2184992 reaction equation
S(Cl)([Cl:3])=O.[C:5]1([NH:11][C:12](=[O:22])[NH:13][C:14]2[CH:21]=[CH:20][C:17]([CH2:18]O)=[CH:16][CH:15]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>ClCCl>[C:5]1([NH:11][C:12](=[O:22])[NH:13][C:14]2[CH:21]=[CH:20][C:17]([CH2:18][Cl:3])=[CH:16][CH:15]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 15895594HCID 15895594, compound

Product 1

HCID 15895595HCID 15895595, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
40 °C

Procedure

42 g (354 mmol) of thionyl chloride were added dropwise at 30° C. to a suspension of 42.8 g (177 mmol) of 4-(3-phenylureido)benzyl alcohol in 500 ml of dichloromethane. The mixture was subsequently stirred at 40° C. for 1 hour. After completion of the evolution of gas, the mixture was allowed to cool to room temperature. The precipitated product was filtered off with suction and washed with dichloromethane. Yield: 44.26 g (96%).

Workup

  1. temperatureto cool to room temperature
  2. filtrationThe precipitated product was filtered off with suction
  3. washwashed with dichloromethane

Sources & evidence

ORD record
ord-0c0666c4cd694d9699850fddb7a14758
Source dataset
uspto-grants-2002_06
Patent number
US06399643B1

Reaction notes

Loading…