2-Bromopyridine → 5-Methyl-2-phenylpyridine

HRID 2185017Notes

Reaction equation

HRID 2185017 reaction equation
[I-].C(O[C:5]([C:7]1[CH:12]=[CH:11][C:10]([Zn+])=[CH:9][CH:8]=1)=O)C.I[C:15]1[CH:20]=[CH:19][CH:18]=CC=1.Br[C:22]1C=CC=C[N:23]=1>>[CH3:18][C:19]1[CH:20]=[CH:15][C:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[N:23][CH:22]=1

Participants

4

Reactant 3

HCID 79732-BromopyridineHCID 11575IodobenzeneHCID 178469116HCID 178469116, compound

Product 1

HCID 474675-Methyl-2-phenylpyridine

Procedure

Following the procedure of Preparation 2(a), except substituting 5-methyl-2-pyridinylzinc bromide for 4-(ethoxycarbonyl)phenylzinc iodide and iodobenzene for 2-bromopyridine. afforded the title compound.

Sources & evidence

ORD record
ord-e44cede548d44d8c9fa54e4501272e48
Source dataset
uspto-grants-2002_06
Patent number
US06399656B1

Reaction notes

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