3-Bromopyridine → 5-Phenyl-2-Thiophenecarboxylic Acid

HRID 2185020Notes

Reaction equation

HRID 2185020 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7](B(O)O)=[CH:6][CH:5]=1)(O)=O.BrC1[S:18][C:17]([C:19]([OH:21])=[O:20])=[CH:16][CH:15]=1.BrC1C=NC=CC=1>>[C:4]1([C:1]2[S:18][C:17]([C:19]([OH:21])=[O:20])=[CH:16][CH:15]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

4

Reactant 3

HCID 122863-BromopyridineHCID 3121834-Carboxyphenylboronic AcidHCID 3491155-Bromothiophene-2-carboxylic acid

Product 1

HCID 7364945-Phenyl-2-Thiophenecarboxylic Acid

Procedure

Following the procedure of Preparation 1(a), except substituting phenylboronic acid for 4-carboxybenzeneboronic acid and 5-bromo-2-thiophenecarboxylic acid for 3-bromopyridine, afforded the title compound.

Sources & evidence

ORD record
ord-fc264f8ce9a64d42841c9616870a57c7
Source dataset
uspto-grants-2002_06
Patent number
US06399656B1

Reaction notes

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