Isopropanol → HCID 178484382, compound

Participants

Reaction Steps

Metformin hydrochloride (49.68 g: 0.3 mol) was dissolved in pure water, and neutralized with 2N sodium hydroxide aqueous solution (150 mL). The mixture was condensed in vacuo until it contained about 30 mL of water. To the mixture was added 2-propanol (300 mL) and stirred at room temperature for 30 minutes. The mixture was filtered and the residue was washed with acetone. The filtrate and the acetone were gathered and the solvent was evaporated in vacuo. Acetone (500 mL) and magnesium sulfate were added to the residue, stirred and filtered. The filtrate was concentrated in vacuo to give free metformin (32.9 g: yield 85%) as white prisms.

Provenance & Evidence