Isopropanol → HCID 178484382, compound

Metformin hydrochloride (49.68 g: 0.3 mol) was dissolved in pure water, and neutralized with 2N sodium hydroxide aqueous solution (150 mL). The mixture was condensed in vacuo until it contained about 30 mL of water. To the mixture was added 2-propanol (300 mL) and stirred at room temperature for 30 minutes. The mixture was filtered and the residue was washed with acetone. The filtrate and the acetone were gathered and the solvent was evaporated in vacuo. Acetone (500 mL) and magnesium sulfate were added to the residue, stirred and filtered. The filtrate was concentrated in vacuo to give free metformin (32.9 g: yield 85%) as white prisms.

1. customcondensed in vacuo until it
2. filtrationThe mixture was filtered
3. washthe residue was washed with acetone
4. customthe solvent was evaporated in vacuo
5. additionAcetone (500 mL) and magnesium sulfate were added to the residue
6. stirringstirred
7. filtrationfiltered
8. concentrationThe filtrate was concentrated in vacuo

ORD record

ord-4bcfffbd5f7d4520aa1f35b8164beebb

Source dataset

uspto-grants-2002_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06399658B1