反应详情

To a stirred solution of ethyl 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]phenoxy]-acetate (120 mg) in ethyl acetate (2.0 ml) was added 4N hydrogen chloride ethyl acetate solution (220 μl) under ice-cooling, and the mixture was vigorously stirred for an hour at room temperature. Collection of the resulting precipitates by filtration gave ethyl 2-[3-chloro-4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-phenoxy]acetate hydrochloride (110 mg).

1. temperaturecooling
2. customCollection of the resulting
3. customprecipitates by filtration