反应详情

A 0° C. solution of the crude product from Step A (12.89 grams; dry dichloromethane; 150 mL) was treated dropwise with 48% HBr (36.0 mL). When outgassing ceased, the solution was warmed to ambient temperature. After 15 minutes, the reaction was partitioned (isopropyl acetate and water), washed twice with water and dried (magnesium sulfate). Filtration and evaporation furnished the title compound as an oil which crystallized on standing,

1. customthe reaction was partitioned (isopropyl acetate and water)
2. washwashed twice with water
3. dry with materialdried (magnesium sulfate)
4. filtrationFiltration and evaporation