Hydrogen Bromide → 1-bromo-4,4-dimethylpentan-2-one

HRID 2185054Notes

Reaction equation

HRID 2185054 reaction equation
[N+](=[CH:3][C:4](=[O:10])[CH2:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[N-].[BrH:11]>C(Cl)Cl>[Br:11][CH2:3][C:4](=[O:10])[CH2:5][C:6]([CH3:9])([CH3:8])[CH3:7]

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 53883486HCID 53883486, compound

Product 1

HCID 2225851-bromo-4,4-dimethylpentan-2-one

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred, −10° solution of the crude product from Step A (1.233 grams) in methylene chloride (12 mL) was added 48% HBr dropwise (1.14 mL). After gas evolution ceased, the reaction was stirred for 15 minutes at room temperature. The reaction was partitioned between isopropyl acetate and water. The organic was washed once with water, dried over magnesium sulfate and filtered. Evaporation afforded an oil containing the title compound which was used without further processing.

Workup

  1. customThe reaction was partitioned between isopropyl acetate and water
  2. washThe organic was washed once with water
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customEvaporation
  6. customafforded an oil

Sources & evidence

ORD record
ord-394f898298f64458915559c1a03466cf
Source dataset
uspto-grants-2002_06
Patent number
US06399640B1

Reaction notes

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