HCID 22459092, compound → HCID 22458924, compound

HRID 2185059Notes

Reaction equation

HRID 2185059 reaction equation
[CH3:1][C:2]([CH3:18])([CH3:17])[CH2:3][C:4]1[C:8]2[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH2:13][CH:14]=[CH2:15])[C:7]=2[O:6][CH:5]=1>C(OC)(C)(C)C.[Pd]>[CH3:17][C:2]([CH3:1])([CH3:18])[CH2:3][C:4]1[C:8]2[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH2:13][CH2:14][CH3:15])[C:7]=2[O:6][CH:5]=1

Participants

4

Reactant 1

HCID 22459092HCID 22459092, compound

Product 1

HCID 22458924HCID 22458924, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 15413tert-Butyl methyl etherSolvent

Procedure

A solution of the product from Step G (1.912 grams) in methyl tert-butyl ether (20 mL) was combined with 5% Pd/C catalyst (200 mg) in a hydrogenation bottle. The mixture was hydrogenated using a Parr apparatus at 14psi for 1 hour. The catalyst was removed by filtration through Celite and the filtrate evaporated. The resultant solid was employed without further purification.

Workup

  1. customfor 1 hour
  2. customThe catalyst was removed by filtration through Celite
  3. customthe filtrate evaporated
  4. customThe resultant solid was employed without further purification

Sources & evidence

ORD record
ord-717cc33e402a4729b8b8d57db0a05596
Source dataset
uspto-grants-2002_06
Patent number
US06399640B1

Reaction notes

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