Triphenylphosphine → (2-Fluoro-5-nitrobenzyl)(triphenyl)phosphonium bromide

Participants

Reaction Steps

20 g (85.5 mmol) of the compound from example 26A are dissolved in 250 ml of anhydrous toluene and admixed with 22.4 g (85.5 mmol) of triphenylphosphine. The solution is heated under reflux for 16 h, in the course of which a precipitate separates out. The mixture is allowed to cool and the precipitate is filtered off. After washing with diethyl ether, it is dried under reduced pressure. This affords 39 g (92% of theory) of the desired product.

Provenance & Evidence