Hydrochloric Acid → HCID 22460057, compound

HRID 2185146Notes

Reaction equation

HRID 2185146 reaction equation
CO[C:3]([N:5]([CH2:16][CH2:17][CH3:18])[CH:6](NCCC)[C:7]([O:9]CC)=[O:8])=O.[CH2:19](NC(NCCC)C(OCC)=O)[CH2:20]C.[ClH:33]>>[ClH:33].[CH2:16]([N:5]([CH2:3][CH2:19][CH3:20])[CH2:6][C:7]([OH:9])=[O:8])[CH2:17][CH3:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 22460062HCID 22460062, compoundHCID 86758125HCID 86758125, compound

Product 1

HCID 22460057HCID 22460057, compoundYield 80%

Procedure

The amino acid di-n-propylglycine can be obtained in the form of its hydrochloride by combining the ethyl N-methoxycarbonyl-2,2-di-n-propylaminoacetate and the ethyl 2,2-di-n-propylaminoacetate and refluxing the mixture with concentrated hydrochloric acid for 12 hours. After cooling, the solution is extracted with MTBE, and the aqueous solution is evaporated to dryness. The residue is taken up again in water, and the solution is evaporated under reduced pressure in order to remove excess hydrochloric acid to leave 43.8 g (80%) of di-n-propylglycine hydrochloride. This can be used to obtain the free amino acid in accordance with known methods.

Workup

  1. temperatureAfter cooling
  2. extractionthe solution is extracted with MTBE
  3. customthe aqueous solution is evaporated to dryness
  4. customthe solution is evaporated under reduced pressure in order
  5. customto remove excess hydrochloric acid

Sources & evidence

ORD record
ord-f0d8c5d24caf4457b8ff6db196f93a9e
Source dataset
uspto-grants-2002_06
Patent number
US06399809B1

Reaction notes

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