N-Acetylsulfanilyl chloride → N-{4-[Methyl-(1-methylpyrrolidin-3-yl)sulfamoyl]phenyl}acetamide

HRID 2185177Notes

Reaction equation

HRID 2185177 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].[CH3:15][NH:16][CH:17]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18]1>>[CH3:15][N:16]([CH:17]1[CH2:21][CH2:20][N:19]([CH3:22])[CH2:18]1)[S:11]([C:8]1[CH:9]=[CH:10][C:5]([NH:4][C:1](=[O:3])[CH3:2])=[CH:6][CH:7]=1)(=[O:13])=[O:12]

Participants

3

Reactant 2

HCID 8481N-Acetylsulfanilyl chlorideHCID 2758520N,1-dimethylpyrrolidin-3-amine

Product 1

HCID 22460074N-{4-[Methyl-(1-methylpyrrolidin-3-yl)sulfamoyl]phenyl}acetamide

Procedure

4-Acetylaminobenzenesulfonyl chloride and methyl-(1-methylpyrrolidin-3-yl)amine are reacted according to the method described in Example 10, intermediate 2. The title compound obtained in the form of a slightly yellowish solid can be reacted further without further purification. (MS-ES+: 312.1; LCMS Rt=0.698 min)

Sources & evidence

ORD record
ord-ed4d82b57f3a4d8b845cb58b2f035ba4
Source dataset
uspto-grants-2002_06
Patent number
US06399824B1

Reaction notes

Loading…