Potassium Carbonate → 1-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene

HRID 2185325Notes

Reaction equation

HRID 2185325 reaction equation
[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[C:14][Si](C)(C)C)=[CH:9][C:8]=2[C:19]([CH3:22])([CH3:21])[CH3:20])[CH2:6][CH2:5]1)[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:3][C:4]1([C:7]2[CH:12]=[CH:11][C:10]([C:13]#[CH:14])=[CH:9][C:8]=2[C:19]([CH3:20])([CH3:22])[CH3:21])[CH2:6][CH2:5]1)[CH3:2]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 22568955[4-(1-Ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-trimethylsilane2×

Product 1

HCID 225688751-(1-Ethoxycyclopropyl)-4-ethynyl-2-tert-butylbenzene

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [4-(1-ethoxycyclopropyl)-3-tert-butyl-phenylethynyl]-trimethylsilane (Intermediate 111, 215.0 mg, 0.69 mmol) in methanol (10 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne, 169 mg, was used directly in the next reaction.

Sources & evidence

ORD record
ord-433fdc394c0c4e2288791b4f9e40035c
Source dataset
uspto-grants-2002_06
Patent number
US06399774B1

Reaction notes

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