反应详情

N-tert-butoxycarbonyl-trans-4-((R)-2-hydroxy-4-phenylbutyrylamino)-L-proline 3-quinolylamide (1.55 g) was dissolved in trifluoroacetic acid (10 mL)-chloroform (20 mL). After stirring for 1 hr, the reaction mixture was evaporated in vacuo. The residue was diluted with chloroform, and washed with saturated sodium hydrogen carbonate. The organic layer was dried over anhydrous sodium sulfate and evaporated in vacuo to give the title compound (888 mg) as a colorless foam.

1. customthe reaction mixture was evaporated in vacuo
2. additionThe residue was diluted with chloroform
3. washwashed with saturated sodium hydrogen carbonate
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. customevaporated in vacuo