Trifluoroacetic acid → HCID 21341481, compound

HRID 2185445Notes

Reaction equation

[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([NH:18][C:19](=[O:37])[C@@H:20]([CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[NH:21]C(OC(C)(C)C)=O)[CH:9]=1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([NH:18][C:19](=[O:37])[C@@H:20]([CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[NH2:21])[CH:9]=1

Participants

Conditions

Temperature: 0 °C

Procedure

Trifluoroacetic acid (2 mL) was added to a solution of N-tert-butoxycarbonyl-D-homophenylalanine 3-quinolylamide (A, 114 mg) in dichloromethane (2 mL) at 0° C. After stirring at 0° C. for 5 min and at room temperature for 40 min, the reaction mixture was evaporated and coevaporated three times with toluene and diethyl ether in vacuo to afford the title compound (151 mg) as a pale yellow solid.

Workup

customthe reaction mixture was evaporated

Sources & evidence

ORD record: ord-518cb7567e0a4678bb46765eed84f785
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06399629B1

Reaction notes

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