HCID 22458654, compound → 4-Phenyl-1-(1-piperazinyl)-1-butanone

HRID 2185472Notes

Reaction equation

HRID 2185472 reaction equation
C([N:5]1[CH2:10][CH2:9][N:8]([C:11](=[O:21])[CH2:12][CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:7][CH2:6]1)(C)(C)C>FC(F)(F)C(O)=O.ClCCl>[C:15]1([CH2:14][CH2:13][CH2:12][C:11]([N:8]2[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]2)=[O:21])[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

4

Reactant 1

HCID 22458654HCID 22458654, compound

Product 1

HCID 224587114-Phenyl-1-(1-piperazinyl)-1-butanone

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

1-tert-Butyl-4-(4-phenylbutanoyl)piperazine (A, 2.64 g) was dissolved in trifluoroacetic acid (10 mL)—dichloromethane (10 mL). After siring for 1 hr, the reaction mixture was evaporated in vacuo. Toluene and methanol were added to the residue, then evaporated in vacuo to give the titled compound (1.63 g) as a colorless solid.

Workup

  1. customthe reaction mixture was evaporated in vacuo
  2. additionToluene and methanol were added to the residue
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-bfb6449b99624b3cb7cbbf25f1504a0d
Source dataset
uspto-grants-2002_06
Patent number
US06399629B1

Reaction notes

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