6-Methoxy-3-pyridinylamine → HCID 17854193, compound

HRID 218555Notes

Reaction equation

HRID 218555 reaction equation
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19](O)=[O:20])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:22][C:23]1[CH:24]=[CH:25][C:26]([O:29][CH3:30])=[N:27][CH:28]=1>>[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH2:11][CH2:12][CH2:13][CH:14]2[C:19]([NH:22][C:23]1[CH:28]=[N:27][C:26]([O:29][CH3:30])=[CH:25][CH:24]=1)=[O:20])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 811216-Methoxy-3-pyridinylamineHCID 112083185-Benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid

Product 1

HCID 17854193HCID 17854193, compoundYield 87.6%

Procedure

By the reaction and treatment in the same manner as in Preparation Example 18 using 5-benzyloxy-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid (20.0 g) and 5-amino-2-methoxypyridine (8.72 g), as starting materials, 5-benzyloxy-N-(6-methoxypyridin-3-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (23.9 g) was obtained.

Workup

  1. customBy the reaction and treatment in the same manner

Sources & evidence

ORD record
ord-7a3e203044ae422e81aafc9b55abb750
Source dataset
uspto-grants-2012_06
Patent number
US08198454B2

Reaction notes

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