Trifluoroacetic acid methylene chloride → HCID 22458254, compound

HRID 2185571Notes

Reaction equation

HRID 2185571 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:25])[CH2:9][CH2:10][CH2:11][CH:12]2[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]2)=[CH:4][CH:3]=1.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27].C(Cl)Cl>>[F:29][C:28]([F:31])([F:30])[C:26]([OH:32])=[O:27].[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:25])[CH2:9][CH2:10][CH2:11][CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 22458261HCID 22458261, compound

Product 1

HCID 22458254HCID 22458254, compound

Procedure

A solution of 4-(4-(4-fluorophenyl)-4-oxo-butyl)-1-tert-butoxycarbonyl-piperidine (184 mg, 0.52 mmol, from Step C) in 30% TFA/CH2Cl2 was stirred for 30 min, then concentrated and dried under vacuum to provide the title compound.

Workup

  1. concentrationconcentrated
  2. customdried under vacuum

Sources & evidence

ORD record
ord-b5f16fb1bf2541b58e4010552fd85250
Source dataset
uspto-grants-2002_06
Patent number
US06399619B1

Reaction notes

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