反应详情

温度

0 °C

To a solution of N-[2-(1,1-dimethylethoxy)-2-oxoethyl]-N-(2-hydroxyethyl)-L-tryptophan 1,1-dimethyl-ethyl ester (4.64 g; 11.09 mmol) in CH2Cl2 (44 mL; freshly distilled over CaH2) under an inert atmosphere, solid Ph3P (2.9 g; 11.09 mmol) was added. The solution was cooled to 0° C. and then solid NBS (1.97 g; 11.09 mmol) was portionwise added (45 min), waiting for complete dissolution after each addition. The reaction was monitored by TLC:

1. additionwas added
2. waitwaiting for complete dissolution
3. additionafter each addition