反应详情

10 g of (R)-1-(phenylmethyl)-3-pyrrolidinol were dissolved in 160 ml of anhydrous toluene. The solution was stirred under a stream of nitrogen, cooled in an ice/ethanol bath and 8.7 ml of triethylamine were added. At a temperature of −5° C. 4,9 ml of a solution of methanesulfonylchloride in 110 ml of anhydrous toluene were added dropwise over 1,5 hours and the reaction mixture was stirred for 1 hour at 0° C. The solid was filtered and washed with ethyl acetate. The filtrate was washed with water, dried and evaporated in vacuo to give 13,9 g of (R)-3-methanesulfonyloxy-1-(phenylmethyl)-pyrrolidine as an almost colourless oil. M.S. (C.I.) (M/Z): 256 [M+H]+.

1. temperaturecooled in an ice/ethanol bath
2. customAt a temperature of −5° C
3. stirringthe reaction mixture was stirred for 1 hour at 0° C
4. filtrationThe solid was filtered
5. washwashed with ethyl acetate
6. washThe filtrate was washed with water
7. customdried
8. customevaporated in vacuo