Butylamine → HCID 9921575, compound

HRID 2185664Notes

Reaction equation

HRID 2185664 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10]([OH:12])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:16]([NH2:20])[CH2:17][CH2:18][CH3:19]>O1CCCC1>[CH2:16]([NH:20][C:10](=[O:12])[C@@H:9]1[CH2:13][CH2:14][CH2:15][N:8]1[C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])[CH2:17][CH2:18][CH3:19]

Participants

4

Reactant 2

HCID 8007ButylamineHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

Product 1

HCID 9921575HCID 9921575, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5.0 g of succinimide ester of N-(tert-butoxycarbonyl)-L-proline (0.016 mmol), marketed by Novabiochem, are dissolved in tetrahydrofuran (50 ml). 1.533 ml of n-butylamine (0.015 mmol) are then added thereto, at 0° C. over 10 minutes, and the mixture is stirred for one hour. The solvent is removed and the resulting crude material is purified by chromatography on silica, using ethyl acetate as eluent. An oil is obtained.

Workup

  1. customThe solvent is removed
  2. customthe resulting crude material is purified by chromatography on silica
  3. customAn oil is obtained

Sources & evidence

ORD record
ord-88cb5f93ede94b84886d839d60f2715a
Source dataset
uspto-grants-2002_06
Patent number
US06403561B1

Reaction notes

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