Methyl 4-methoxy-2,3-dihydro-1H-indole-2-carboxylate → 4-Methoxyindoline-2(r/s)-carboxylic acid butylamide

Participants

Reaction Steps

Methyl 4-methoxyindoline-2(R/S)-carboxylate (0.89 g, 4.3 mmol) was dissolved in butylamine (40 ml) under nitrogen and the solution was then stirred at reflux for three hours. After cooling the mixture, the remaining butylamine was removed under vacuum. The crude product was recrystallized from diethyl ether in order to give an off-white solid.

Provenance & Evidence