HCID 14691534, compound → HCID 23313846, compound

HRID 2185682Notes

Reaction equation

HRID 2185682 reaction equation
[CH3:1][C:2]1([CH3:16])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=[C:3]1[C:11]([O:13][CH2:14][CH3:15])=[O:12]>C(O)C.[Pd]>[CH3:1][C:2]1([CH3:16])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][CH:3]1[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 1

HCID 14691534HCID 14691534, compound

Product 1

HCID 23313846HCID 23313846, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Ethyl 3,3-dimethyl-3H-indole-2-carboxylate (4.00 g, 18.4 mmol) was dissolved in ethanol (20 ml) and activated palladium-on-charcoal (0.5 g) was then added to this solution. This mixture was hydrogenated for five hours. After filtration in order to remove the catalyst, the filtrate was dried (MgSO4) and the solvent removed in order to give a brown oil.

Workup

  1. filtrationAfter filtration in order
  2. customto remove the catalyst
  3. dry with materialthe filtrate was dried (MgSO4)
  4. customthe solvent removed in order
  5. customto give a brown oil

Sources & evidence

ORD record
ord-aa28a24f8b2e4f17b2040e653840eb2d
Source dataset
uspto-grants-2002_06
Patent number
US06403561B1

Reaction notes

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