HCID 22451271, compound → HCID 77752253, compound

HRID 2185700Notes

Reaction equation

HRID 2185700 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]([C:11]([O:13]C)=O)[CH2:5]2>C(N)CCC>[CH2:6]([NH:7][C:11]([CH:6]1[CH2:5][C:4]2[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=2)[NH:7]1)=[O:13])[CH2:5][CH2:4][CH3:3]

Participants

3

Reactant 1

HCID 22451271HCID 22451271, compound

Product 1

HCID 77752253HCID 77752253, compound

Reagents, catalysts & solvents 1

HCID 8007ButylamineSolvent

Procedure

Methyl 5-chloroindoline-2(R/S)-carboxylate (0.63 g, 3 mmol) was dissolved in butylamine (25 ml) and refluxed for 4 h. The excess amine was removed and the residue was crystallized from ether to give a yellow solid.

Workup

  1. temperaturerefluxed for 4 h
  2. customThe excess amine was removed
  3. customthe residue was crystallized from ether
  4. customto give a yellow solid

Sources & evidence

ORD record
ord-57d20b3d7f1e4e0e88619c851ce551d0
Source dataset
uspto-grants-2002_06
Patent number
US06403561B1

Reaction notes

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