(Chloromethyl)cyclopropane → 2-Cyclopropylmethyl-4-methoxycarbonyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one

HRID 2185793Notes

Reaction equation

HRID 2185793 reaction equation
[CH3:1][O:2][C:3]([C:5]1[C:6](=[O:19])[NH:7][N:8]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([S:17][CH3:18])=[CH:13][CH:12]=2)[CH:10]=1)=[O:4].Cl[CH2:21][CH:22]1[CH2:24][CH2:23]1>>[CH:22]1([CH2:21][N:7]2[C:6](=[O:19])[C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:10][C:9]([C:11]3[CH:16]=[CH:15][C:14]([S:17][CH3:18])=[CH:13][CH:12]=3)=[N:8]2)[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 80013(Chloromethyl)cyclopropaneHCID 219916864-methoxycarbonyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one

Product 1

HCID 129717712-Cyclopropylmethyl-4-methoxycarbonyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-oneYield 61.5%

Procedure

Using 4-methoxycarbonyl-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one and (chloromethyl)cyclopropane as starting materials, the procedures of Example 1 were repeated likewise, whereby the title compound was obtained in a yield of 61.5%.

Sources & evidence

ORD record
ord-22ed990121e24acea820e279beda1364
Source dataset
uspto-grants-2002_06
Patent number
US06403586B1

Reaction notes

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