Ethanolamine → HCID 22452221, compound

HRID 2185811Notes

Reaction equation

HRID 2185811 reaction equation
C(O[C:4]([CH2:6][N:7]1[C:12](=[O:13])[C:11]([C:14](=[O:17])[NH:15][CH3:16])=[CH:10][C:9]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)=[N:8]1)=[O:5])C.[NH2:26][CH2:27][CH2:28][OH:29]>CO>[OH:29][CH2:28][CH2:27][NH:26][C:4]([CH2:6][N:7]1[C:12](=[O:13])[C:11]([C:14](=[O:17])[NH:15][CH3:16])=[CH:10][C:9]([C:18]2[CH:19]=[CH:20][C:21]([O:24][CH3:25])=[CH:22][CH:23]=2)=[N:8]1)=[O:5]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 22452283HCID 22452283, compound

Product 1

HCID 22452221HCID 22452221, compoundYield 91%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In methanol, 2-ethoxycarbonylmethyl-6-(4-methoxyphenyl)-4-methylcarbamoyl-2H-pyridazin-3-one and 2-aminoethanol were heated under reflux for 4 hours. Post-treatments were conducted as in Example 43, whereby the title compound was obtained in a yield of 91.0%.

Workup

  1. temperatureunder reflux for 4 hours

Sources & evidence

ORD record
ord-a308a2fba97147c18a11a908186803df
Source dataset
uspto-grants-2002_06
Patent number
US06403586B1

Reaction notes

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