HRID2185876

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22452665

未命名化合物

结构：CNC[C@@H](CCN1CCC(c2ccccc2[S@](C)=O)CC1)c1ccc(Cl)c(Cl)c1

HCID57302211

未命名化合物

PRODUCTS

生成物

结构：CN(C[C@@H](CCN1CCC(c2ccccc2[S@](C)=O)CC1)c1ccc(Cl)c(Cl)c1)C(=O)c1ccc([N+](=O)[O-])c2c1CCCC2

HCID70161198

未命名化合物

PROCEDURE

实验过程

Using a procedure analogous to that described in Example 3, N-[(S)-2-(3,4-dichlorophenyl)4-[4-[(S)-2-methylsulfinylphenyl]-1-piperidinyl]butyl]-N-methylamine was reacted with 4-nitro-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride [prepared from 4-nitro-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid (T. Nakayama, T. Okutome, R. Matsui, M. Kurumi, Y. Sakurai, T. Aoyama, S. Fujii, Chem. Pharm. Bull. 32(10) 3968 (1984))] and the product was converted to the citrate salt MS: m/z 656 (M+H). Analysis for C34H39Cl2N3O4S.C6H8O7.1.0H2O: calculated: C, 54.42; H, 5.70; N, 4.85. found: C, 55.03; H, 5.55; N, 4.94.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7eb94af1736d4407901e5a81edf156c0
来源数据集: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06403601B1
来源说明: uspto-grants-2002_06

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[S@:27]([CH3:29])=[O:28])[CH2:17][CH2:16]2)[CH2:10][NH:11][CH3:12])[CH:5]=[CH:6][C:7]=1[Cl:8].[N+:30]([C:33]1[C:42]2[CH2:41][CH2:40][CH2:39][CH2:38][C:37]=2[C:36]([C:43](Cl)=[O:44])=[CH:35][CH:34]=1)([O-:32])=[O:31]>>[Cl:1][C:2]1[CH:3]=[C:4]([C@H:9]([CH2:13][CH2:14][N:15]2[CH2:16][CH2:17][CH:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[S@:27]([CH3:29])=[O:28])[CH2:19][CH2:20]2)[CH2:10][N:11]([CH3:12])[C:43]([C:36]2[C:37]3[CH2:38][CH2:39][CH2:40][CH2:41][C:42]=3[C:33]([N+:30]([O-:32])=[O:31])=[CH:34][CH:35]=2)=[O:44])[CH:5]=[CH:6][C:7]=1[Cl:8]