4-Nitro-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride → N-[(S)-2-(3,4-Dichlorophenyl)4-[4-[(S)-2-methylsulfinylphenyl]-1-piperidinyl]butyl]-N-methyl-4-nitro-5,6,7,8-tetrahydro-1-naphthamide

Participants

Reaction Steps

Using a procedure analogous to that described in Example 3, N-[(S)-2-(3,4-dichlorophenyl)4-[4-[(S)-2-methylsulfinylphenyl]-1-piperidinyl]butyl]-N-methylamine was reacted with 4-nitro-5,6,7,8-tetrahydro-1-naphthalenecarbonyl chloride [prepared from 4-nitro-5,6,7,8-tetrahydro-1-naphthalenecarboxylic acid (T. Nakayama, T. Okutome, R. Matsui, M. Kurumi, Y. Sakurai, T. Aoyama, S. Fujii, Chem. Pharm. Bull. 32(10) 3968 (1984))] and the product was converted to the citrate salt MS: m/z 656 (M+H). Analysis for C34H39Cl2N3O4S.C6H8O7.1.0H2O: calculated: C, 54.42; H, 5.70; N, 4.85. found: C, 55.03; H, 5.55; N, 4.94.

Provenance & Evidence