反应详情

温度

22.5 °C

A mixture of 0.66 g of Compound 8A and 0.07 g of Raney-Nickel in 20 mL of ethyl acetate was stirred for 14 hours at 20-25° C. The catalyst was filtered off. The mixture was diluted with water. The organic layer was separated and the mixture extracted with 2×40 mL of ethyl acetate. The combined organic layers were washed with 20 mL of brine, dried over sodium sulphate and evaporated to dryness in vacuo to afford 0.52 g (90.6%) of Compound 8B as an oil.

1. filtrationThe catalyst was filtered off
2. additionThe mixture was diluted with water
3. customThe organic layer was separated
4. extractionthe mixture extracted with 2×40 mL of ethyl acetate
5. washThe combined organic layers were washed with 20 mL of brine
6. dry with materialdried over sodium sulphate
7. customevaporated to dryness in vacuo