Hydrogen Bromide → 1-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

HRID 2185923Notes

Reaction equation

HRID 2185923 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:14]C)=[C:6]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=1.[BrH:16]>>[BrH:16].[BrH:16].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:14])=[C:6]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 2735754HCID 2735754, compound

Product 1

HCID 234479081-(5-Chloro-2-hydroxyphenyl)piperazine dihydrobromide

Procedure

A suspension of 5.5 g of 1-(5-chloro-2-methoxyphenyl)piperazine in 40 mL of 62% hydrobromic acid was stirred at reflux for 30 hours. After cooling to room temperature the mixture was filtered by suction and the solid was washed on the funnel with acetone affording 6.02 g of the title compound. M.p.>270° C. (ethanol).

Workup

  1. temperatureat reflux for 30 hours
  2. filtrationwas filtered by suction
  3. washthe solid was washed on the funnel with acetone affording 6.02 g of the title compound

Sources & evidence

ORD record
ord-b5b8d4754fe64f44b7a713d3becbb443
Source dataset
uspto-grants-2002_06
Patent number
US06403594B1

Reaction notes

Loading…