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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2186058Generated: November 4, 2026

p-METHYLACETOPHENONE → 4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione

https://huagongshe.com/reaction/2186058

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-METHYLACETOPHENONEHCID 8500—
ReactantEthyl trifluoroacetateHCID 9794—
Product4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dioneHCID 550193—

Reaction Steps

In the step 2, the p-Methyl acetophenone was condensed with Ethyltrifluoroacetate under alkaline conditions to give the 1-(4-Methylphenyl)-4,4,4-trifluorobutane-1,3-dione intermediate.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06403629B2
Source datasetuspto-grants-2002_06
ORD IDord-4f7e73ad391f4a20bbb81231cd5d7a1c
Source noteuspto-grants-2002_06