p-METHYLACETOPHENONE → 4,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione

HRID 2186058Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.C([O:13][C:14](=O)[C:15]([F:18])([F:17])[F:16])C>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH2:9][C:14](=[O:13])[C:15]([F:18])([F:17])[F:16])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 8500p-METHYLACETOPHENONE

HCID 9794Ethyl trifluoroacetate

Product 1

HCID 5501934,4,4-Trifluoro-1-(4-methylphenyl)butane-1,3-dione

Procedure

In the step 2, the p-Methyl acetophenone was condensed with Ethyltrifluoroacetate under alkaline conditions to give the 1-(4-Methylphenyl)-4,4,4-trifluorobutane-1,3-dione intermediate.

Sources & evidence

ORD record: ord-4f7e73ad391f4a20bbb81231cd5d7a1c
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06403629B2

Reaction notes

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