HCID 54450914, compound → HCID 54029713, compound

HRID 2186140Notes

Reaction equation

HRID 2186140 reaction equation
[C:1]([N:4]1[CH2:9][CH2:8][C:7]([CH2:14][N:15]2[CH:20]=[CH:19][N:18](C(OCC3C=CC=CC=3)=O)[CH2:17][C:16]2=[O:31])([C:10]([O:12][CH3:13])=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>[Pd].CO>[C:1]([N:4]1[CH2:5][CH2:6][C:7]([CH2:14][N:15]2[CH2:20][CH2:19][NH:18][CH2:17][C:16]2=[O:31])([C:10]([O:12][CH3:13])=[O:11])[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

Participants

4

Reactant 1

HCID 54450914HCID 54450914, compound

Product 1

HCID 54029713HCID 54029713, compoundYield 84.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-(1-acetyl-4-methoxycarbonylpiperidin-4-ylmethyl)-4-benzyloxycarbonyl-2-oxo-1,2,3,4-tetrahydropyrazine (2.4 g) and 10% palladium on carbon (500 mg) in methanol (100 ml) was stirred at room temperature for 15 hours, under hydrogen atmosphere, and the catalyst was filtered off. The reaction solution was concentrated to give colorless oil of the title compound (1.40 g).

Workup

  1. filtrationthe catalyst was filtered off
  2. concentrationThe reaction solution was concentrated

Sources & evidence

ORD record
ord-7f09fce0d1734a029d1b0e0b516a1611
Source dataset
uspto-grants-2002_06
Patent number
US06403595B1

Reaction notes

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