2-Bromo-1-(1,3-thiazol-2-ylthio)ethane → Methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(1,3-thiazol-2-ylthio)ethyl]piperidine-3-carboxylate

HRID 2186358Notes

Reaction equation

HRID 2186358 reaction equation
[O:1]=[C:2]([C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][CH:16]=1)[CH2:3][CH2:4][C@@H:5]1[CH2:10][CH2:9][NH:8][CH2:7][C@@H:6]1[C:11]([O:13][CH3:14])=[O:12].Br[CH2:28][CH2:29][S:30][C:31]1[S:32][CH:33]=[CH:34][N:35]=1>>[O:1]=[C:2]([C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[C:22]([O:25][CH3:26])[CH:23]=2)[N:18]=[CH:17][CH:16]=1)[CH2:3][CH2:4][C@@H:5]1[CH2:10][CH2:9][N:8]([CH2:28][CH2:29][S:30][C:31]2[S:32][CH:33]=[CH:34][N:35]=2)[CH2:7][C@@H:6]1[C:11]([O:13][CH3:14])=[O:12]

Participants

3

Reactant 2

HCID 224530772-Bromo-1-(1,3-thiazol-2-ylthio)ethaneHCID 53238173(3R,4R)-methyl 4-(3-(6-methoxyquinolin-4-yl)-3-oxopropyl)piperidine-3-carboxylate

Product 1

HCID 86758156Methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(1,3-thiazol-2-ylthio)ethyl]piperidine-3-carboxylate

Procedure

Methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(1,3-thiazol-2-ylthio)ethyl]piperidine-3-carboxylate was prepared, by analogy with Example 4, from methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate and 2-bromo-1-(1,3-thiazol-2-ylthio)ethane.

Sources & evidence

ORD record
ord-011d58a6c0e14eff9877630036e766bb
Source dataset
uspto-grants-2002_06
Patent number
US06403610B1

Reaction notes

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