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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2186358Generated: October 30, 2026

2-Bromo-1-(1,3-thiazol-2-ylthio)ethane → Methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(1,3-thiazol-2-ylthio)ethyl]piperidine-3-carboxylate

https://huagongshe.com/reaction/2186358

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-1-(1,3-thiazol-2-ylthio)ethaneHCID 22453077—
Reactant(3R,4R)-methyl 4-(3-(6-methoxyquinolin-4-yl)-3-oxopropyl)piperidine-3-carboxylateHCID 53238173—
ProductMethyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(1,3-thiazol-2-ylthio)ethyl]piperidine-3-carboxylateHCID 86758156—

Reaction Steps

Methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]-1-[2-(1,3-thiazol-2-ylthio)ethyl]piperidine-3-carboxylate was prepared, by analogy with Example 4, from methyl (3R,4R)-4-[3-oxo-3-(6-methoxyquinolin-4-yl)propyl]piperidine-3-carboxylate and 2-bromo-1-(1,3-thiazol-2-ylthio)ethane.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06403610B1
Source datasetuspto-grants-2002_06
ORD IDord-011d58a6c0e14eff9877630036e766bb
Source noteuspto-grants-2002_06