(3,5-Diisopropylphenyl)boronic acid → 1-tert-Butyl-4,4-dimethyl-3,4-dihydro-naphthalen-7-boronic acid

HRID 2186415Notes

Reaction equation

HRID 2186415 reaction equation
C(C1C=C([B:13]([OH:15])[OH:14])C=C(C(C)C)C=1)(C)C.[C:16]([C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27](Br)[CH:28]=2)[C:23]([CH3:32])([CH3:31])[CH2:22][CH:21]=1)([CH3:19])([CH3:18])[CH3:17]>>[C:16]([C:20]1[C:29]2[C:24](=[CH:25][CH:26]=[C:27]([B:13]([OH:15])[OH:14])[CH:28]=2)[C:23]([CH3:32])([CH3:31])[CH2:22][CH:21]=1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 11543001(3,5-Diisopropylphenyl)boronic acid2×HCID 158960196-Bromo-4-tert-butyl-1,1-dimethyl-1,2-dihydronaphthalene2×

Product 1

HCID 224561651-tert-Butyl-4,4-dimethyl-3,4-dihydro-naphthalen-7-boronic acid

Procedure

Employing the procedure used for the preparation of 3,5-diisopropylphenylboronic acid (Compound 2), 1-tert-butyl-4,4-dimethyl-3,4-dihydro-7-bromonaphthalene (Compound 16) was converted to the title compound. The resulting crude product was used in the next step without further purification. 1-tert-butyl-4,4-dimethyl-3,4-dihydro-7-bromonaphthalene (Compound 16) can be obtained in accordance with the disclosure of U.S. Pat. No. 5,741,896, incorporated herein by reference.

Sources & evidence

ORD record
ord-3f0b104346384be2866365c0918ca686
Source dataset
uspto-grants-2002_06
Patent number
US06403638B1

Reaction notes

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