HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2186446Generated: October 26, 2026
Morpholine → 7-Bromo-4-methoxy-2-(morpholin-4-yl)-benzooxazole
https://huagongshe.com/reaction/2186446
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 7-Bromo-4-methoxy-2-methylsulfanylbenzooxazole | HCID 22456651 | — |
| Product | 7-Bromo-4-methoxy-2-(morpholin-4-yl)-benzooxazole | HCID 22456657 | — |
Reaction Steps
A mixture of 7-bromo-4-methoxy-2-methylsulfanylbenzooxazole (10.0 g) and morpholine (6.6 ml) were heated at 80° C. for 18 hours. Purification by chromatography on silica eluting with 20-100% ethyl acetate in heptane afforded the title compound as an off-white solid (11.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06403791B1 |
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| Source dataset | uspto-grants-2002_06 |
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| ORD ID | ord-dbf4b158d40c4f529ad1063a144de0d7 |
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| Source note | uspto-grants-2002_06 |
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