7-Bromo-4-methoxy-2-(piperidin-1-yl)-benzooxazole → 7-Bromo-2-(piperidin-1-yl)-benzooxazol-4-ol

HRID 2186450Notes

Reaction equation

HRID 2186450 reaction equation
[Br:1][C:2]1[C:10]2[O:9][C:8]([N:11]3[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]3)=[N:7][C:6]=2[C:5]([O:17]C)=[CH:4][CH:3]=1>C(OCC)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:17])=[C:6]2[C:10]=1[O:9][C:8]([N:11]1[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1)=[N:7]2

Participants

3

Reactant 1

HCID 224566607-Bromo-4-methoxy-2-(piperidin-1-yl)-benzooxazole

Product 1

HCID 224566497-Bromo-2-(piperidin-1-yl)-benzooxazol-4-olYield 86.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Starting from 7-bromo-4-methoxy-2-(piperidin-1-yl)-benzooxazole (9.0 g). Trituration in diethyl ether afforded the title compound as a pale brown solid (7.46 g).

Sources & evidence

ORD record
ord-1fb576c0dcc84b5f8dcdcb811f895419
Source dataset
uspto-grants-2002_06
Patent number
US06403791B1

Reaction notes

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