HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-1-methyl-1H-pyrazol-5-amine → 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (4-bromo-2-methyl-2H-pyrazol-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-1-methyl-1H-pyrazol-5-amine | HCID 600351 | — |
| Reactant | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitrophenyl ester | HCID 54536097 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (4-bromo-2-methyl-2H-pyrazol-3-yl)-amide | HCID 10273269 | 6.4% |
Reaction Steps
Starting from 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitro-phenyl ester (100 mg) and 4-bromo-2-methyl-2H-pyrazol-3-ylamine (93 mg). Purification by column chromatography on silica eluting with 1-5% methanol in dichloromethane afforded, after trituration with diethyl ether, the title compound as a white solid (7 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06403791B1 |
| Source dataset | uspto-grants-2002_06 |
| ORD ID | ord-f37cfa70122e455ca0c51294c7801dd5 |
| Source note | uspto-grants-2002_06 |