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5-amino-1-methyl-1H-imidazole-4-carbonitrile → 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (5-cyano-3-methyl-3H-imidazol-4-yl)-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-amino-1-methyl-1H-imidazole-4-carbonitrile | HCID 11051635 | — |
| 反応物 | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitrophenyl ester | HCID 54536097 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 4-Difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid (5-cyano-3-methyl-3H-imidazol-4-yl)-amide | HCID 10292045 | 34.6% |
反応手順
Starting from 4-difluoromethoxy-2-ethylbenzooxazole-7-carboxylic acid 4-nitro-phenyl ester (100 mg) and 5-amino-1-methyl-1H-imidazole-4-carbonitrile (65 mg). Purification by column chromatography on silica eluting with 0-5% methanol in ethyl acetate afforded, after trituration with diethyl ether, the title compound as a white solid (33 mg)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06403791B1 |
| 出典データセット | uspto-grants-2002_06 |
| ORD ID | ord-9cb91b7778c042c59aca1a7a31f8931c |
| 出典メモ | uspto-grants-2002_06 |