反应详情

温度

70 °C

In a 1 liter four-necked flask were charged 200 g (1.11 mol) of methyl (S)-3-hydroxy-3-phenylpropionate (optical purity: 87%e.e.), 77.8 g (1.56 mol) of hydrazine monohydrate, and 400 ml of methanol, and the mixture was heated at 70° C. for 3 hours. The reaction mixture was cooled to 5° C. with ice-water, followed by filtration. The collected crystals were dissolved in 4.7 liter of methanol while hot and cooled to 5° C. The crystals thus precipitated were collected by filtration and dried to give 148 g (74%) of the title compound. Melting point: 179.5° C. Optical purity: >99.9%e.e.

1. filtrationfollowed by filtration
2. dissolutionThe collected crystals were dissolved in 4.7 liter of methanol while hot and
3. temperaturecooled to 5° C
4. customThe crystals thus precipitated
5. filtrationwere collected by filtration
6. customdried