Ethyl Acetate → HCID 54557405, compound

HRID 2186502Notes

Reaction equation

HRID 2186502 reaction equation
[N:1]([CH2:4][C@H:5]([O:12]C(=O)CCCCC)[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])=[N+]=[N-].C([O:23][CH2:24][CH3:25])(=O)C>[Pd]>[C:24]([NH:1][CH2:4][C@H:5]([OH:12])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8])(=[O:23])[CH2:25][CH2:4][CH2:5][CH2:6][CH3:7]

Participants

4

Reactant 2

HCID 8857Ethyl AcetateHCID 53814266HCID 53814266, compound

Product 1

HCID 54557405HCID 54557405, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a 200 ml autoclave were charged 8.50 g (29.5 mmol) of ethyl (R)-4-azido-3-hexanoyloxybutyrate, 0.20 g of 5% Pd—C, and 16 ml of ethyl acetate, and the mixture was stirred at room temperature under a hydrogen pressure of 1000 KPa. for 7 hours. The catalyst was removed for concentration to give 7.07 g (87%) of the title compound.

Workup

  1. customThe catalyst was removed for concentration

Sources & evidence

ORD record
ord-34926ba34b704ad994e8a359fe94eb9b
Source dataset
uspto-grants-2002_06
Patent number
US06403804B1

Reaction notes

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