Sodium Iodide → HCID 59191187, compound

HRID 218655Notes

Reaction equation

[CH3:1][N:2]([CH3:33])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][N:10]([C:24]2[CH:29]=[CH:28][C:27]([CH:30]([CH3:32])[CH3:31])=[CH:26][CH:25]=2)[C:11]([CH:13]2[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([OH:23])[CH:21]=3)[CH2:16][CH2:15][CH2:14]2)=[O:12])=[CH:5][CH:4]=1.Cl.Cl[CH2:36][CH2:37][N:38]([CH3:40])[CH3:39].[I-].[Na+]>>[CH3:39][N:38]([CH3:40])[CH2:37][CH2:36][O:23][C:20]1[CH:21]=[C:22]2[C:17]([CH2:16][CH2:15][CH2:14][CH:13]2[C:11]([N:10]([CH2:9][C:6]2[CH:7]=[CH:8][C:3]([N:2]([CH3:33])[CH3:1])=[CH:4][CH:5]=2)[C:24]2[CH:25]=[CH:26][C:27]([CH:30]([CH3:31])[CH3:32])=[CH:28][CH:29]=2)=[O:12])=[CH:18][CH:19]=1

Participants

Reactant 3

HCID 5238Sodium Iodide

HCID 10275168HCID 10275168, compound

HCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

Product 1

HCID 59191187HCID 59191187, compoundYield 6.2%

Procedure

By the reaction and treatment in the same manner as in Example 110 using N-[(4-dimethylaminophenyl)methyl]-7-hydroxy-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (0.5 g), 2-chloro-N,N-dimethylethylamine hydrochloride (0.36 g) and sodium iodide (0.51 g) as starting materials, 7-[2-(dimethylamino)ethoxy]-N-[(4-dimethylaminophenyl)methyl]-N-(4-isopropylphenyl)-1,2,3,4-tetrahydronaphthalene-1-carboxamide (36 mg) was obtained.

Sources & evidence

ORD record: ord-3ee154e22ffc4998adc5a47215811a72
Source dataset: uspto-grants-2012_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08198454B2

Reaction notes

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