Potassium Hydroxide → HCID 136383543, compound

HRID 2186677Notes

Reaction equation

HRID 2186677 reaction equation
C([S:4][CH2:5][CH2:6][O:7][N:8]=[C:9]1[C:13](=[N:14][O:15][CH3:16])[C:12]2[CH:17]=[CH:18][CH:19]=[CH:20][C:11]=2[O:10]1)(=O)C.[OH-].[K+]>CO>[CH3:16][O:15][N:14]=[C:13]([C:9]1[S:4][CH2:5][CH2:6][O:7][N:8]=1)[C:12]1[CH:17]=[CH:18][CH:19]=[CH:20][C:11]=1[OH:10]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 73782577HCID 73782577, compound

Product 1

HCID 136383543HCID 136383543, compoundYield 24.7%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Process c) 3.67 g (0.0125 mol) of S-[2-(3-methoxyimino-3H-benzofuran-2-ylideneaminooxy)-ethyl] thioacetate in 40 ml of methanol are heated under reflux with 12.5 ml of 2N aqueous potassium hydroxide solution for 15 minutes. The solvent is then distilled off under reduced pressure and the residue is admixed with 2N aqueous hydrochloric acid. The mixture is extracted with diethyl ether, the organic phase is dried over sodium sulphate and the solvent is distilled off under reduced pressure. The residue is stirred with diethyl ether, giving 0.78 g (24.7% of theory) of (5,6-dihydro-[1,4,2]oxathiazin-3-yl)-(2-hydroxyphenyl)-methanone O-methyloxime.

Workup

  1. distillationThe solvent is then distilled off under reduced pressure
  2. extractionThe mixture is extracted with diethyl ether
  3. dry with materialthe organic phase is dried over sodium sulphate
  4. distillationthe solvent is distilled off under reduced pressure

Sources & evidence

ORD record
ord-eba101e960ff4570a817ef40ab2b3215
Source dataset
uspto-grants-2002_06
Patent number
US06407097B1

Reaction notes

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