反应详情

3-(2-hydroxyethyl)-2,3-dihydrobenzofuran-7-yloxyacetic acid (2.91 g) was dissolved in ethanol (30 ml), and (−)-cis-2-benzylaminocyclohexanemethanol (1.88 g) was added to the resultant solution, followed by reflux and dissolution. Ethyl acetate (15 ml) was then added to the resultant solution, and the mixture was cooled to room temperature to obtain crystals. The thus-obtained crystals were filtered off, and then recrystallized 6 times from ethanol to obtain the object compound of 97%e.e (0.77 g, yield 14%).

1. temperatureby reflux
2. dissolutiondissolution
3. customto obtain crystals
4. filtrationThe thus-obtained crystals were filtered off
5. customrecrystallized 6 times from ethanol
6. customto obtain the object compound of 97%e.e (0.77 g, yield 14%)