Trifluoroacetic acid → HCID 70156863, compound

HRID 2186819Notes

Reaction equation

C(OC([N:8]1[CH2:13][C@@H:12]2[CH2:14][C@H:9]1[CH2:10][N:11]2[C:15]([N:17]1[CH2:22][CH2:21][CH:20]([C:23]2[NH:27][N:26]=[C:25]3[C:28]4[C:33]([C:34](=[O:35])[C:24]=23)=[C:32]([NH:36][C:37](=[O:45])[NH:38][N:39]2[CH2:44][CH2:43][O:42][CH2:41][CH2:40]2)[CH:31]=[CH:30][CH:29]=4)[CH2:19][CH2:18]1)=[O:16])=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[C@H:12]12[CH2:14][C@H:9]([NH:8][CH2:13]1)[CH2:10][N:11]2[C:15]([N:17]1[CH2:18][CH2:19][CH:20]([C:23]2[NH:27][N:26]=[C:25]3[C:28]4[C:33]([C:34](=[O:35])[C:24]=23)=[C:32]([NH:36][C:37](=[O:45])[NH:38][N:39]2[CH2:44][CH2:43][O:42][CH2:41][CH2:40]2)[CH:31]=[CH:30][CH:29]=4)[CH2:21][CH2:22]1)=[O:16]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 21350056HCID 21350056, compound

Product 1

HCID 70156863HCID 70156863, compound

Procedure

Prepared in a similar fashion as described for example CXXVI, step 7, using the 3-(1-((5-t-butoxycarbonyl-(1S,4S)-(+)- 2,5-diazabicyclo[2.2.1]hept-2-yl)carbonyl)piperidin-4-yl)-5-(morpholinocarbamoylamino)indeno[1,2-c]pyrazol-4-one as the starting material. mp 196-198° C. (TFA salt); ESI-MS (M+H) calc'd for C26H33N8O4: 521.2613, found: 521.2613.

Workup

customPrepared in a similar fashion

Sources & evidence

ORD record: ord-88ede828279f4c4e8eaaeda5688fb20c
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06407103B2

Reaction notes

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