Trifluoroacetic acid → HCID 178521855, compound

HRID 2186820Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]([C@H:16]2[CH2:21][CH2:20][C@H:19]([C:22]3[NH:26][N:25]=[C:24]4[C:27]5[C:32]([C:33](=[O:34])[C:23]=34)=[C:31]([NH:35][C:36](=[O:44])[NH:37][N:38]3[CH2:43][CH2:42][O:41][CH2:40][CH2:39]3)[CH:30]=[CH:29][CH:28]=5)[CH2:18][CH2:17]2)=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[N:11]1([C:14]([C@H:16]2[CH2:21][CH2:20][C@H:19]([C:22]3[NH:26][N:25]=[C:24]4[C:27]5[C:32]([C:33](=[O:34])[C:23]=34)=[C:31]([NH:35][C:36](=[O:44])[NH:37][N:38]3[CH2:39][CH2:40][O:41][CH2:42][CH2:43]3)[CH:30]=[CH:29][CH:28]=5)[CH2:18][CH2:17]2)=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 178452362HCID 178452362, compound

Product 1

HCID 178521855HCID 178521855, compound

Procedure

Prepared in a similar fashion as described for exampleCXXVI, step 7, using 3-(trans-4-(4-(t-butoxycarbonyl)piperazinocarbonyl)cyclohexyl)-5-(morpholinocarbamoylamino)indeno[1,2-c]pyrazol-4-one as the starting material. mp 247-248° C. (TFA salt); ESI-MS (M+H) calc'd for C26H34N7O4: 508.2672, found: 508.2670.

Workup

customPrepared in a similar fashion

Sources & evidence

ORD record: ord-c67f114f1c144005a4e34aad0a121de3
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06407103B2

Reaction notes

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