Sodium Iodide → HCID 11748163, compound

Temperature

60 °C

[2-(acetylamino)ethyl] chloromethyl carbonate (5.0 g) was dissolved in acetonitrile (15 ml), and sodium iodide (15.0 g) was added. The mixture was stirred at 60° C. for 2 hours under an argon atmosphere. The reaction mixture was poured into ice water (200 ml) and extracted with ethyl acetate (200 ml). The extract was washed with an aqueous 5% sodium thiosulfate solution (100 ml×2), water (100 ml×2) and a saturated sodium chloride aqueous solution (50 ml) successively. After drying over anhydrous magnesium sulfate, the solvent was distilled off under reduced pressure to obtain [2-(acetylamino)ethyl] iodomethyl carbonate (3.5 g) as a yellow oil.

1. extractionextracted with ethyl acetate (200 ml)
2. washThe extract was washed with an aqueous 5% sodium thiosulfate solution (100 ml×2), water (100 ml×2)
3. dry with materialAfter drying over anhydrous magnesium sulfate
4. distillationthe solvent was distilled off under reduced pressure

ORD record

ord-3cefd11499154d3d8be5a1fb4fbebcf1

Source dataset

uspto-grants-2002_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06407129B1