Ethyl 4-bromobutyrate → HCID 17795934, compound

HRID 2187074Notes

Reaction equation

Br[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6].[O:10]=[C:11]1[N:20]([CH2:21][CH2:22][CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][CH:28]([O:31][CH:32]([C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH2:27][CH2:26]2)[C:19](=[O:45])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[NH:12]1>>[O:10]=[C:11]1[N:20]([CH2:21][CH2:22][CH2:23][CH2:24][N:25]2[CH2:26][CH2:27][CH:28]([O:31][CH:32]([C:39]3[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=3)[C:33]3[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=3)[CH2:29][CH2:30]2)[C:19](=[O:45])[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[N:12]1[CH2:2][CH2:3][CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6]

Participants

Reactant 2

HCID 76300Ethyl 4-bromobutyrate

HCID 22449569HCID 22449569, compound

Product 1

HCID 17795934HCID 17795934, compound

Procedure

Using the method similar to that in Example 57 and ethyl 4-bromobutyrate instead of 1-bromo-2-phenylethane and starting from 2,4-dioxo-3-[4-(4-diphenylmethoxypiperidino)butyl]-1,2,3,4-tetrahydroquinazoline (1.00 g) obtained in Example 80, the title compound was obtained as a crystal. This product was used in the next reaction without further purification.

Sources & evidence

ORD record: ord-5f5416ad9d4c4c608662c290bdb372e7
Source dataset: uspto-grants-2002_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06407116B1

Reaction notes

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